Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes
Mao, S.-j.; Hou, S.-x.; Jin, H.; Zhang, L.-k.; Jiang-Bin
Zhongguo Zhong Yao Za Zhi 28(4): 328-331
2003
ISSN/ISBN: 1001-5302 PMID: 15139140 Document Number: 561633
To study the preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes. 3-succinic-30-stearyl glycyrrhetinic acid(Suc-GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface-modified with glycyrrhetinic acid has been produced with ethanol injection method. Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes. Liposomes surface-modified with glycyrrhetinic acid was successfully prepared, which is considered to be a potential approach targeting to hepatocytes.