Targeting therapy with a drug using temperature-sensitive liposomes entrapped antitumor drug together with localized hyperthermia
Ogawa, Y.; Toguchi, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 17(6): 1127-1133
1990
ISSN/ISBN: 0385-0684 PMID: 2350189 Document Number: 367442
The characteristics and feasibility of targeting therapy with combination of temperature-sensitive liposomes entrapped antitumor drug with localized hyperthermia were discussed on the theoretical as well as experimental basis. An optimum liposome form and a drug for this delivery were proposed as follows: the liposome is LUV which has a phase transition temperature of 41 to 42 degree and the osmotic pressure of the internal aqueous phase is 1.5 or higher than the physiological one, the drug has a large body clearance and has a synergistic effect with hyperthermia. The LUV preparation containing cisplatin was administered to mice together with tumor heating. The uptake of the drug in the tumor (as a criterion of targeting) were 3 to 5 times greater than those of an aqueous cisplatin solution. The tumor responses were well correlated with the drug-targeting.