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Heat-sensitive liposomes containing cisplatin and localized hyperthermia in treatment of murine tumor

Nishita, T.

Osaka City Medical Journal 44(1): 73-83

1998

ISSN/ISBN: 0030-6096
PMID: 9834620
Document Number: 485784
Combined therapy with heat-sensitive liposomes as carriers for drugs and local hyperthermia is thought to improve the local control rate. I studied the antitumor effects and concentrations of CDDP encapsulated in heat-sensitive liposomes (LIP-CDDP) in vivo. LIP-CDDP or CDDP-solution was given to 8 week-old male C3H/He mice bearing SCC VII tumors by tail vein injection, and tumors were heated at 40 degrees C or 42 degrees C. The concentration of LIP-CDDP in blood was significantly higher than that of CDDP-solution. The concentration in tumors after heating at 42 degrees C increased with heating time, but the concentration in tumors without heating or after heating at 40 degrees C did not show these changes. After heating at 42 degrees C, antitumor effects of LIP-CDDP were significantly better than those obtained with the use of CDDP-solution. Heating at 40 degrees C did not alter the antitumor effect of LIP-CDDP. Therefore, LIP-CDDP proved to be very effective when combined with local hyperthermia at 42 degrees C.

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Weinstein, J.N.; Magin, R.L.; Cysyk, R.L.; Zaharko, D.S. 1980: Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate Cancer Research 40(5): 1388-1395
Ogawa, Y.; Toguchi, H. 1990: Targeting therapy with a drug using temperature-sensitive liposomes entrapped antitumor drug together with localized hyperthermia Gan to Kagaku Ryoho. Cancer and ChemoTherapy 17(6): 1127-1133
Mansouri, A.; Henle, K.J.; Benson, A.M.; Moss, A.J.; Nagle, W.A. 1989: Characterization of a cisplatin-resistant subline of murine RIF-1 cells and reversal of drug resistance by hyperthermia Cancer Research 49(10): 2674-2678
Walton, M.I.; Bleehen, N.M.; Workman, P. 1989: Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice Cancer Research 49(9): 2351-2355
Leserman, L.D.; Weinstein, J.N.; Blumenthal, R.; Sharrow, S.O.; Terry, W.D. 1979: Binding of antigen-bearing fluorescent liposomes to the murine myeloma tumor MOPC 315 Journal of Immunology 122(2): 585-591
Yang, J.; Tang, L.; Peng, Y.; Zhang, F.; Yan, M. 2014: Pretreatment with cisplatin plus hyperthermia kills different tumor cells but preserves the erythrocyte function in the intra-operative blood salvage in vitro Zhonghua Yi Xue Za Zhi 94(7): 495-498
Kumar, A.; Singh, S.M.; Sodhi, A. 1997: Effect of tumor cells on the activation of murine lymphocytes and macrophages by cisplatin and FK565 Neoplasma 44(5): 319-323
Herman, T.S.; Teicher, B.A.; Coleman, C.N. 1990: Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo Cancer Research 50(16): 5055-5059
Calamai, P.; Carotti, S.; Guerri, A.; Mazzei, T.; Messori, L.; Mini, E.; Orioli, P.; Speroni, G.P. 1998: Cytotoxic effects of gold(III) complexes on established human tumor cell lines sensitive and resistant to cisplatin Anti-Cancer Drug Design 13(1): 67-80
Ueno, M.; Zou, Y.Y.; Yamagishi, M.; Horikoshi, I. 1989: Basic study on hepatic artery chemoembolization and tumor selective drug targeting by temperature-sensitive liposome with local hyperthermia Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(12): 3735-3738
Pace, M.; Pirillo, M.; Lauri, G.; Lenzi, A. 1982: Hyperthermia in the treatment of malignant tumors. Analysis of the various methods of induction of the heat Minerva Chirurgica 37(20): 1803-1807
Johnson, S.W.; Swiggard, P.A.; Handel, L.M.; Brennan, J.M.; Godwin, A.K.; Ozols, R.F.; Hamilton, T.C. 1994: Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells Cancer Research 54(22): 5911-5916
Fichtinger-Schepman, A.M.; Vendrik, C.P.; van Dijk-Knijnenburg, W.C.; de Jong, W.H.; van der Minnen, A.C.; Claessen, A.M.; van der Velde-Visser, S.D.; de Groot, G.; Wubs, K.L.; Steerenberg, P.A. 1989: Platinum concentrations and DNA adduct levels in tumors and organs of cisplatin-treated LOU/M rats inoculated with cisplatin-sensitive or -resistant immunoglobulin M immunocytoma Cancer Research 49(11): 2862-2867
Xie, Y.-F.; Ruan, Y.-D.; Ning, X.-J.; Ma, C.-L.; Chen, Y. 2010: Heat sensitive moxibustion for treatment of nerve root cervical spondylosis Zhongguo Zhen Jiu 30(5): 379-382
Stehlin, J.S.; Greeff, P.J.; Giovanella, B.C.; Williams, L.J. 1980: Dramatic response of cancer to localized hyperthermia New York State Journal of Medicine 80(1): 70-72
Frost, P.; Kerbel, R.S.; Hunt, B.; Man, S.; Pathak, S. 1987: Selection of metastatic variants with identifiable karyotypic changes from a nonmetastatic murine tumor after treatment with 2'-deoxy-5-azacytidine or hydroxyurea: implications for the mechanisms of tumor progression Cancer Research 47(10): 2690-2695
Strnad, V.; Tacev, T.; Prokes, B.; Ott, O.; Krystof, V.; Svobodova, M.; Rasovska, O.; Konecny, M. 1990: Tumor response and treatment complications in radiotherapy of localized prostate cancer Strahlentherapie und Onkologie: Organ der Deutschen Rontgengesellschaft . 166(11): 728-732
Jardon, O.M. 1985: Heat stroke, stress, and malignant hyperthermia Nebraska Medical Journal 70(6): 195-199
Venugopalan, P.; Jain, S.; Sankar, S.; Singh, P.; Rawat, A.; Vyas, S.P. 2002: PH-sensitive liposomes: mechanism of triggered release to drug and gene delivery prospects Die Pharmazie 57(10): 659-671
Lucke, J.N.; Hall, G.M.; Lister, D. 1977: Anaesthesia of pigs sensitive to malignant hyperthermia Veterinary Record 100(3): 45-48