Liquid chromatographic determination of pyrantel tartrate in medicated formulations
Konrardy, J.A.; Burner, M.A.; Garner, T.W.; Litchman, M.A.; Webster, G.K.
Journal - Association of Official Analytical Chemists 86(5): 882-887
2003
ISSN/ISBN: 0004-5756 PMID: 14632387 Document Number: 559623
The validation of a novel liquid chromatographic (LC) method for the determination of pyrantel tartrate in feed is presented. The method provides a significant improvement over the efficiency and precision of AOAC Official Method 978.30. The method was shown to be accurate, precise, linear, and robust for medicated articles. Unlike the official method, the LC method was shown to be a superior stability-indicating method. After the method was validated by using laboratory blends, the effectiveness of the method was demonstrated with marketed product as well.