High-performance liquid chromatographic investigation of the interaction of phenylmercuric nitrate and sodium metabisulphite in eye drop formulations
Parkin, J.E.
Journal of Chromatography 511: 233-242
1990
ISSN/ISBN: 0021-9673 PMID: 2211913 Document Number: 363551
The degradation of phenylmercuric nitrate in the presence of sodium metabisulphite in eye drop formulations has been investigated using a stability-indicating high-performance liquid chromatographic (HPLC) method. HPLC methods have been developed for the quantitation of the principal degradation products (diphenyl-mercury, benzenesulphonic acid and benzenesulphinic acid) and a mechanism is proposed for their formation. The pharmaceutical significance of the interaction is briefly discussed.