Pathogenesis of experimentally produced mouse adenovirus infection in mice
Heck, F.C.; Sheldon, W.G.; Gleiser, C.A.
American Journal of Veterinary Research 33(4): 841-846
1972
ISSN/ISBN: 0002-9645 PMID: 4336084 Document Number: 55648
Inoculation of unweaned mice with either a massive dose (20000 median lethal doses) or small dose (100 LD50) of mouse adenovirus resulted in uniform clinical manifestations of infection characterized by ruffled coat, lethargy, stunted growth, and, terminally, a tendency to burrow in the cage bedding. Adult mice responsed serologically but without clinical signs. Viraemia was detectable in unweaned mice as early as the 1st day after inoculation and persisted as long as 6 additional days. Tissue-associated virus was detected by mouse inoculation in the heart, kidney, spleen, and brain on days 3 and 5. Characteristic inclusions were seen in the brain sections of injected mice (a lesion not previously reported). Specific CF antibody was detected in young mice within 12 days after infection.