Statistical test on multivariate in therapeutical equivalence analysis
Yan, Y.-X.; Wang, H.-Y.; Wang, R.-A.
Zhonghua Liu Xing Bing Xue Za Zhi 24(10): 935-938
2003
ISSN/ISBN: 0254-6450 PMID: 14575613 Document Number: 554588
To explore the way for testing of multivariate in therapeutical equivalence. By improved Hotelling T(2) test, the mean vector of two groups was tested. The information of each variable could then be obtained by deducting the their correlations. "Clinical Equivalence of Drug A and Drug B for Postmenopausal Bone Looseness" was used in this research. The primary measure of efficacy was regarded as the improvement rate of four variables with predefined limit of equivalence (2%) with the results of univariate test and multivariate test compared. Under P > alpha, all the variables were nonequivalent. Under P