Morphological and physiological variations in chloroquine-resistant Plasmodium berghei, Vincke and Lips, 1948

Peters, W.

Annales des Societes Belges de Medecine Tropicale, de Parasitologie et de Mycologie 45(3): 365-376

1965


ISSN/ISBN: 0037-9638
PMID: 5853642
Document Number: 5513
A strain of P. berghei resistant to chloroquine (Rc) and a second resistant to both chloroquine and the active triazine metabolite of proguanil (c) exhibit the following differences from the normal parent strain: 1. They produce a less severe and more slowly developing infection in untreated mice. 2. RC and c strain trophozoites contain numerous food vacuoles whereas normal trophozoites contain only one or two. 3. RC and c strain trophozoites and schizonts fail to produce normal haemozoin. 4. The intra-erythrocytic trophozoites reproduce by binary fission as well as by schizogony. The resistance to chloroquine in both RC and c strains is rapidly lost in the absence of drug selection pressure. Resistance to triazine in the c strain remains stable.

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Morphological and physiological variations in chloroquine-resistant Plasmodium berghei, Vincke and Lips, 1948