In vitro chloroquine-resistant Plasmodium falciparum malaria in the Natal/Kwazulu area
Herbst, J.M.; Taylor, L.A.; Joubert, S.M.
South African Medical Journal 68(10): 749-750
1985
ISSN/ISBN: 0256-9574 PMID: 3904037 Document Number: 264778
Blood samples from 77 patients with Plasmodium falciparum malaria resident in the Natal/Kwazulu area, were treated for chloroquine resistance by an in vitro microtechnique; 6 of these patients were infected by asexual parasites which proved resistant in varying degrees to chloroquine. Resistance, expressed in terms of picomoles chloroquine base per well in which schizont development was completely inhibited, ranged from 16 pmol to greater than 24 pmol. On the evidence it would appear likely that these patients were infected during visits to Mozambique or areas immediately bordering Mozambique.