Effect of ethanol on intracellular Ca2+ metabolism
Babich, L.G.; Shlykov, S.G.; Borisova, L.A.
Ukrains'kyi Biokhimichnyi Zhurnal 74(1): 19-26
2002
ISSN/ISBN: 0372-3909 PMID: 12199095 Document Number: 550863
The aim of this review is to summarize current thinking on ethanol effects on the Ca2+ homeostasis in the excitable tissue cells. It has been shown that acute exposure to ethanol decreases cytoplasmic Ca2+ concentration due to Ca2+ channels inhibition and Ca2+ pumps activation. Whereas chronic exposure to ethanol increases the intracellular Ca2+ concentration in cells due to activation of passive Ca2+ transport systems and inhibition of energy-dependent Ca2+ transport systems. The emphasis is place on a possible role of pharmacologic agents that preserve Ca2+ homeostasis in protecting against ethanol-induced diseases.