Pharmacoepidemiological modelling: Markov models of antibiotic use in patients with diabetes
Leufkens, H.G.M.
Netherlands Journal of Medicine 60(7 Suppl) 78-80; Discussion: 80-82
2002
ISSN/ISBN: 0300-2977 PMID: 12430594 Document Number: 549194
The importance of time patterns in drug exposure is increasingly recognised in the evaluation of determinants and outcomes of pharmacotherapy. Data on patterns of drug exposure over time in individual patients and populations have been found to provide important 'fingerprint' information on temporal relations between disease course and severity, drug effects, and prognosis. However, data on prescriptions of medicines always need to be interpreted in the light of complementary data on clinical status, diagnosis, co-morbidity and the like.