Elastolytic system of the pancreas in modelling diabetes mellitus
Borysiuk, M.V.; Dosenko, V.I.; Byts', I.V.
Fiziolohichnyi Zhurnal 48(5): 17-21
2002
ISSN/ISBN: 2522-9028 PMID: 12449609 Document Number: 544280
At modelling streptozotocin and alloxan diabetes mellitus in rats we have detected an imbalance between elastase and its inhibitors (alpha 1 inhibitor of protein kinases, alpha-2 macroglobulin, acid-thermoresistant inhibitors) in tissues of the pancreas. The contribution of proelactase decreased but that of an active form of protein kinase increased; the content of alpha 1 inhibitor of protein kinase and alpha 2 macroglobulin reduced, however, the contribution of the acid-thermoresistant inhibitors in the pancreatic tissues increased. Imbalance in the system elastase-inhibitors, shown at the model of diabetes mellitus, may be an important mechanism of an exocrine insufficiency of the pancreas which results in pancreatitis.