Dynamics of redistribution of blood serum lipoproteins in patients with alcoholism during alcohol intoxication and its abolition
Bozhko, G.K.; Artemchuk, A.F.; Chursina, V.S.; Artemchuk, A.A.
Ukrains'kyi Biokhimichnyi Zhurnal 74(5): 120-123
2002
ISSN/ISBN: 0372-3909 PMID: 12916168 Document Number: 547003
In the patients with alcoholism at intoxication and different periods of alcohol abolition the blood serum lipoproteins were investigated by a method of gradient gel-electrophoresis using the computer program for qualitative definition. It was found out that change of the total sum of all lipoprotein fractions was approximated to parabolic dependence with maximum in the 3rd day after alcohol abolition. Under intoxication disturbances the individual apoB-containing fractions were minimal as compared with the control, while at the initial stages of alcohol abolition their redistribution was noticed as reflecting the growth of the processes of cholesterol transportation from liver to peripheral tissues. The 14th day after alcohol abolition was characterized by tendency to normalization of these disturbances, but at the 30th day of soberness a recurrence growing the changes of apoA-containing lipoproteins transformation was observed. In the patients under intoxication period and first 3 days after alcohol abolition a significant increase of quantity of all the apoA-containing lipoprotein populations took place which was restored completely in remission. On the base of both the own results and data from literature sources we suppose that these changes are the results of direct influence of ethanol and but they are not a pathogenic indication of a chronic alcoholism.