A lipid emulsion reduces mortality from clomipramine overdose in rats
Yoav, G.; Odelia, G.; Shaltiel, C.; Goor, Y.; Goor, O.; Cabili, S.
Veterinary and Human Toxicology 44(1): 30
2002
ISSN/ISBN: 0145-6296 PMID: 11824772 Document Number: 546692
Tricyclic antidepressants are a common cause of self poisoning. Since these drugs are highly lipid soluble, we examined the interaction between imipramine and a lipid emulsion. Rats were given an iv dose of imipramine with either normal saline or a lipid emulsion as vehicle. The rats who received the lipid emulsion had a significantly lower mortality. The role of lipid emulsions poisoning therapy is reviewed.
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