Influence of rapid amino acid and lipid emulsion administration on gas exchange and resting energy expenditure
Sobotka, L.; Zadak, Z.; Bures, J.; Pidrman, V.
Nutrition 7(3): 200-3; discussion 203-4
1991
ISSN/ISBN: 0899-9007 PMID: 1802208 Document Number: 380792
The effect of rapid lipid and amino acid infusion on resting energy expenditure (REE) was examined in 8 patients 30 to 50 years old on parenteral nutrition. After 8 h of saline administration, they received 20% lipid emulsion and 8% amino acid solution during the next 5 h (rate 3.8 mg kg-1 min-1 fat and 1.9 mg kg-1 min-1 amino acid). Before the onset of the infusion and 3 and 5 h after, gas exchange and REE were measured. The rapid lipid emulsion administration led to a significant rise in serum triacylglycerols. A significant increase in VO2 (from 269.0+or-66.8 to 319+or-55.8 ml/min) and REE (from 1858+or-438 to 2155+or-385 kcal/24 h) was observed 5 h after the onset of substrate administration (P<0.01). Pulmonary ventilation and VCO2 production were not influenced by the infusion. The thermic effect of nutrients administered reached 3.5 and 6.5% 3 and 5 h after the start of infusion, respectively. It is concluded that REE can be increased by the rapid administration of lipid-based parenteral nutrition.