Glucose and fat utilization during intravenous administration of glucose and lipid emulsion in non-insulin-dependent diabetic patients
Pelikánová, T.; Krausová, Z.; Kohout, M.; Válek, J.; Basĕ, J.
Nutrition 9(1): 18-22
1993
ISSN/ISBN: 0899-9007 PMID: 8467106 Document Number: 413223
To evaluate the clinical significance of substrate competition in the insulin-resistant state, glucose and lipid utilization were measured in 10 non-insulin-dependent diabetic patients (46.4+or-3.6 years old) during an isoglycaemic hyperinsulinaemic (about 75 and 1500 mU/litre) clamp without and with the concomitant infusion of Intralipid (triglycerides 0.15 g kg-1 h-1) and during Intralipid infusion only in combination with indirect calorimetry. It was found that a lipid emulsion does not alter the metabolic clearance rates of glucose at insulinaemias of about 75 (5.58+or-2.56 vs. 6.03+or-2.43) and about 1500 mU/litre (13.55+or-3.17 vs. 13.75+or-4.36 ml kg-1 min-1) and it does not change oxidative and nonoxidative glucose disposal rates. Insulin and glucose attenuate the Intralipid-induced increase in serum triglycerides, free fatty acids and lipid oxidation. It is concluded that, whereas Intralipid infused at a standard rate does not decrease glucose utilization under hyperinsulinaemic conditions, its own removal from the plasma is enhanced by glucose and insulin in non-insulin-dependent diabetic patients.