Top Abstract Purchase Related
Home
>
Node
>
Subnode

Inhibitors of 5-lipoxygenase

Gápovský, M.; Remko, M.

Ceska a Slovenska Farmacie Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti 51(2): 55-62

2002

ISSN/ISBN: 1210-7816
PMID: 11928277
Document Number: 546481
Leukotrienes are powerful mediators of inflammation processes. Possibilities of their biosynthesis inhibition have been intensively studied during recent two decades aiming to develop new methods of therapy of various inflammatory diseases, particularly asthma. Biosynthesis of all leukotrienes is dependent on the production of the key intermediate LTA4. Transformation of arachidonic acid to LTA4 is catalyzed by the enzyme 5-lipoxygenase and facilitated by FLAP. The present paper discusses the results of recent development of new drugs in this area.

Document emailed within 1 workday
Secure & encrypted payments

Falkenhein, S.F.; Macdonald, H.; Huber, M.M.; Koch, D.; Parker, C.W. 1980: Effect of the 5-hydroperoxide of eicosatetraenoic acid and inhibitors of the lipoxygenase pathway on the formation of slow reacting substance by rat basophilic leukemia cells; direct evidence that slow reacting substance is a product of the lipoxygenase pathway Journal of Immunology 125(1): 163-168
Nuhn, P.; Büge, A.; Köhler, T.; Lettau, H.; Schneider, R. 1991: Trends in the development of lipoxygenase inhibitors Die Pharmazie 46(2): 81-88
Grupe, R.; Ziska, T.; Richter, A.; Böhme, B.; Göres, E. 1988: Lipoxygenase inhibitors and mast cell degranulation Biomedica Biochimica Acta 47(12): 955-963
Bibikova, M.V.; Spiridonova, I.A.; Danilenko, A.N.; Kim, Y.A.; Korystova, A.F.; Shaposhnikova, V.V.; Korystov, Y.N. 2016: Screening of Organisms Producing Inhibitors of 15-Lipoxygenase Among Micromycetes Antibiotiki i Khimioterapiia 61(7-8): 3-9
Presenz, P. 1997: Lipoamino acids and lipopeptides as potential 5- and 12-lipoxygenase inhibitors Die Pharmazie 52(2): 164-165
Lototskaia, L.S.; Naĭdenova, I.I.; Il'iasheva, L.M.; Poda, G.I.; Kornilov, A.I. 1989: Soy lipoxygenase as the object for the primary testing of potential inhibitors of leukotriene biosynthesis Farmakologiia i Toksikologiia 52(2): 59-62
Evans, J.F.; Lévillé, C.; Mancini, J.A.; Prasit, P.; Thérien, M.; Zamboni, R.; Gauthier, J.Y.; Fortin, R.; Charleson, P.; MacIntyre, D.E. 1991: 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors Molecular Pharmacology 40(1): 22-27
Beno, D.W.; Mullen, J.; Davis, B.H. 1995: Lipoxygenase inhibitors block PDGF-induced mitogenesis: a MAPK-independent mechanism that blocks fos and egr American Journal of Physiology 268(3 Pt 1): C604-C610
Zarnack, S.; Bekemeier, H.; Giessler, A.J. 1988: Inhibition of arachidonic acid-induced ear edema in the mouse with lipoxygenase-, cyclo-oxygenase- and dual inhibitors Die Pharmazie 43(5): 337-338
Ishihara, Y.; Uchida, Y.; Kitamura, S.; Takaku, F. 1983: Effect of lipoxygenase inhibitors, AA-861 and T-22083, on chemical mediators release from sensitized guinea pig lung tissue Nihon Kyobu Shikkan Gakkai Zasshi 21(10): 984-987
Rahman, A.; Imran, H.; Iqbal, L.; STaqvi, S.I.H.; Fatima, N.; Yaqeen, Z. 2016: Dry and ripe fruit of Aegle marmelos. L: a potent source of antioxidant, lipoxygenase inhibitors and free radical scavenger Pakistan Journal of Pharmaceutical Sciences 29(4): 1127-1131
Kelly, J.P.; Johnson, M.C.; Parker, C.W. 1979: Effect of inhibitors of arachidonic acid metabolism on mitogenesis in human lymphocytes: possible role of thromboxanes and products of the lipoxygenase pathway Journal of Immunology 122(4): 1563-1571
Bekemeier, H.; Hirschelmann, R.; Langner, A.; Giessler, A.J.; Krause, E.; Funke, T.; Hänsel, F.; Schmidt, K.; Zarnack, S.; Schumann, H.H. 1989: The pharmacology of the lipoxygenase inhibitors oxphaman (1-(2,5-dihydroxybenzylidene)aminoadamantane) and oxphalin (1-(3,4-dihydroxybenzylidene)-2,4,6-trimethylaniline Die Pharmazie 44(8): 550-555
Nyby, M.D.; Sasaki, M.; Ideguchi, Y.; Wynne, H.E.; Hori, M.T.; Berger, M.E.; Golub, M.S.; Brickman, A.S.; Tuck, M.L. 1996: Platelet lipoxygenase inhibitors attenuate thrombin- and thromboxane mimetic-induced intracellular calcium mobilization and platelet aggregation Journal of Pharmacology and Experimental Therapeutics 278(2): 503-509
Verburg, A.F.E.; van den Donk, M.; Wiersma, T. 2019: Application of new glucose lowering drugs: DPP-4 inhibitors, GLP-1 receptor agonists and SGLT-2 inhibitors Nederlands Tijdschrift Voor Geneeskunde 163
Sumathi, S.; Pattabiraman, T.N. 1976: Natural plant enzyme inhibitors: Part II-protease inhibitors of seeds Indian Journal of Biochemistry and Biophysics 13(1): 52-56
Carter, G.W.; Young, P.R.; Albert, D.H.; Bouska, J.; Dyer, R.; Bell, R.L.; Summers, J.B.; Brooks, D.W. 1991: 5-lipoxygenase inhibitory activity of zileuton Journal of Pharmacology and Experimental Therapeutics 256(3): 929-937
Bondarenko, L.B.; Kharchenko, O.V.; Butovich, I.A. 1995: Effect of 1,25-dihydroxyvitamin D3 on 15-lipoxygenase activity Voprosy Meditsinskoi Khimii 41(3): 29-31
Tang, K.; Honn, K.V. 1997: Lipoxygenase metabolites and cancer metastasis Advances in Experimental Medicine and Biology 422: 71-84
Bhat, P.G.; Karnik, S.S.; Pattabiraman, T.N. 1976: Natural plant enzyme inhibitors: Part III-purification of protease inhibitors from Lathyrus sativus seeds Indian Journal of Biochemistry and Biophysics 13(4): 339-343