Inhibition of arachidonic acid-induced ear edema in the mouse with lipoxygenase-, cyclo-oxygenase- and dual inhibitors

Zarnack, S.; Bekemeier, H.; Giessler, A.J.; Zarnack, S; Bekemeier, H; Giessler, A.J

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Inhibition of arachidonic acid-induced ear edema in the mouse with lipoxygenase-, cyclo-oxygenase- and dual inhibitors

Zarnack, S.; Bekemeier, H.; Giessler, A.J.

Die Pharmazie 43(5): 337-338

1988

ISSN/ISBN: 0031-7144

PMID: 3140256

Document Number: 319227

The ear edema of the mouse induced by local application of arachidonic acid is suitable for in vivo differentiation of lipoxygenase (LOX) and cyclooxygenase (COX) inhibitors. LOX blockers inhibit initially and plateau-like during the first hour of the course of the edema, while COX-blockers do so mostly only initially. For practice we recommend the measurement about 60 min following edema provocation. The dual blocker of LOX and COX, BW 755 c, acts like a LOX inhibitor.