Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets
Gualde, N.; Atluru, D.; Goodwin, J.S.
Journal of Immunology 134(2): 1125-1129
1985
ISSN/ISBN: 0022-1767 PMID: 2981258 Document Number: 251303
The lipoxygenase products LTB4thymidine incorporation into T cell preparation enriched for cells bearing the cytotoxic suppressor cell phenotype identified by the OKT8 monoclonal antibody. The mitogen response of T cells enriched for OKT4+ helper-inducer cells is inhibited in a manner similar to the response of unfractionated T cells. Thus, LTB4 and 15 HPETE stimulate both the function and the proliferation of the cytotoxic-suppressor T cell subset.