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Metabolic interactions between glucose and fructose

Malaisse, W.J.

Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 157(7-9) 349-352; Discussion: 352-353

2002

ISSN/ISBN: 0377-8231
PMID: 12647375
Document Number: 544452
Fructose-1-phosphate, the product of fructose phosphorylation by fructokinase, favours glucose phosphorylation by glucokinase, at the intervention of a regulatory protein. Glucose confers to glucokinase positive cooperativity, towards fructose. These reciprocal effects are operative in hepatocytes and pancreatic islets. They could optimize their glucostatic function.

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