Effect of irbesartan, an antagonist of AT-1 receptors for angiotensin II, on L-arginine metabolism in arterial hypertension
Kotsiuruba, A.V.; Svishchenko, I.P.; Bukhanevich, O.M.; Kosiakova, H.V.; Berdyshev, A.H.; Radchenko, V.V.; Mishchenko, L.A.; Hula, N.M.
Fiziolohichnyi Zhurnal 48(3): 22-28
2002
ISSN/ISBN: 2522-9028 PMID: 12125280 Document Number: 544400
Effects of an antagonist of AT-1 receptors for angiotensin-II (Ang-II) irbezantane on the NO-synthase and arginase ways of the metabolism of L-arginine were studied in plasma and erythrocytes of the patients with arterial hypertension. The intensity of the non-oxidative arginase way of L-arginine metabolism in plasma and erythrocytes has been shown to be inhanced at hypertension versus the normotensive patients, while the activity of the alternative oxidative NO-synthase way was reduced. Inhibiting AT-1 receptors for Ang-II with high-affinity antagonist irbezantane normalized the ratio between two alternative ways of L-arginine metabolism through inhibiting the arginase way and reciprocal activating the NO-synthase way both in human plasma and erythrocytes.