The effect of angiotensin II antagonist on hypoxemia
Sakio, H.; Oode, H.; Taneyama, C.; Mita, H.; Usui, Y.; Nagayama, T.; Okuda, C.
Masui. Japanese Journal of Anesthesiology 34(7): 973-977
1985
ISSN/ISBN: 0021-4892 PMID: 4057548 Document Number: 254927
The role of angiotensin II (A-II) in the pulmonary circulation during hypoxic condition and the effects of A-II antagonist on pulmonary function remain uncertain. A preventive effect of a specific A-II antagonist, 1-sar-8-ile-A-II (DD3489), on experimental hypoxemia and during general anesthesia was evaluated. Saline solution (3 ml/kg) was administered into the trachea with or without a 40 min i.v. infusion of A-II antagonist (5 .mu.g/kg per min) in 6 dogs. Mean arterial PO2 [O2 pressure] recovered significantly by infusion of this antagonist, when compared to that without its infusion, although it was still lower than the initial levels. This antagonist was then infused at a rate of 100 ng/kg per min over 30 min 8 patients who showed a relatively low arterial PO2 during general anesthesia. Arterial PO2 (FIO2 = 0.5) increased significantly from 113 .+-. 10 mm Hg-170 .+-. 12 mm Hg at the end of infusion in 5 patients. In the remaining 3 patients, arterial PO2 was unchanged during infusion. A-II antagonist may improve the ventilation-perfusion relationship, and therefore this antagonist might be a useful therapeutic agent in the treatment of hypoxemia.