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A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans

Chen, Y.; Zhou, L.; Xu, Y.; Shen, H.; Niu, J.

Zhonghua Yu Fang Yi Xue Za Zhi 36(3): 191-194

2002

ISSN/ISBN: 0253-9624
PMID: 12410955
Document Number: 541964
Objective: To study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans. Methods: A case-control study based on 154 type 2 diabetes mellitus and 130 healthy controls was carried out in Jiangsu Province in 1997. Results: The age, family history of diabetes mellitus, hypertension history, high waist/hip ratio (WHR), high systolic blood pressure, huge fetus history, and the genotype of beta3-adrenergic receptor (beta3-AR) were the risk factors of type 2 diabetes mellitus; while occupational physical activity was protective factor of type 2 diabetes mellitus. The risk for diabetes mellitus distinctly increased while genetic factor and obesity, beta3-AR mutation were coexisting. Conclusion: Type 2 diabetes mellitus is caused by the effect of both genetic and environmental factors.

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