Medico-genetic counselling of the relatives of patients with type I diabetes mellitus
Kuraeva, T.L.; Sergeev, A.S.; Mazovetskiĭ, A.G.; Koroleva, A.G.
Problemy Endokrinologii 37(2): 14-17
1991
ISSN/ISBN: 0375-9660 PMID: 1857692 Document Number: 380620
Population-genetic surveys show that for the relatives of patients with type I diabetes mellitus (the 1st degree of kinship) a risk of developing the same type of diabetes is 2-5%. Tables of repeated risk of developing diabetes mellitus (DM) of type I for persons with a different number of relatives affected by this type of DM were calculated on the basis of analysis of 2000 family histories of DM patients (a random sampling). A risk of developiong this disease is in direct correlation with the number of sick and healthy relatives and their age. The presence of patients with type II DM in a family does not influence the risk of developing type 1 DM. Risk assessments are of prognostic rather than diagnostic value. The effectiveness of medicogenetic counseling can be increased with the help of various genetic markers, associated with type I DM. Risk assessment must lay the basis of a follow-up of persons with aggravated heredity by investigating immunological, hormonal and metabolic derangements in them.