Predicting outcome in hematological stem cell transplantation
Dickinson, A.M.; Cavet, J.; Cullup, H.; Wang, X.N.; Jarvis, M.; Sviland, L.; Middleton, P.G.
Archivum Immunologiae et Therapiae Experimentalis 50(6): 371-378
2002
ISSN/ISBN: 0004-069X PMID: 12546063 Document Number: 541733
This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-alpha, IFN-gamma, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell transplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain cytokine gene polymorphisms may be associated with more severe disease.
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