Autologous transplantation of peripheral blood hematopoietic stem cells in the treatment of hematological malignancies. I: patients
Medinger, P.; Tissot, J.D.; Nicoloso de Faveri, G.; Kovacsovics, T.J.; Perey, L.; Schneider, P.; Zwicky, C.
Schweizerische Medizinische Wochenschrift 130(13): 478-484
2000
ISSN/ISBN: 0036-7672 PMID: 10812643 Document Number: 513767
61 autologous transplantations for haematological malignancies have been performed with peripheral blood stem cells in 60 patients. 26 grafts were performed for non-Hodgkin's lymphoma (18 patients were transplanted in first remission, 8 patients after progression or relapse), 13 for multiple myeloma, 7 for Hodgkin's disease and 10 for acute myeloid leukaemia. One patient died from thrombosis of the portal vein. 38 patients were in complete remission 29 months (extremes: 14-44) after transplantation. 21 of 60 patients progressed or relapsed after transplantation, and 14 died. No death was attributed to graft failure, infection or haemorrhage. In conclusion, transplantation with peripheral blood stem cells is well tolerated, has a low toxicity rate, and can be used safely for patients with haematological malignancies.