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In vitro assessment of the interaction mechanisms between mucin and a cationic cellulosic derivative by rheological methods using an experimental design

Weyenberg, W.; Ludwig, A.

Die Pharmazie 57(9): 628-631

2002

ISSN/ISBN: 0031-7144
PMID: 12369451
Document Number: 541422
An oscillatory rheological method is used for the determination of the mucoadhesive properties of a cationic cellulosic derivative (JR-30M) proposed for ocular dosage forms and dry eye viscous solutions. An experimental design was set up to study the influence of the concentrations of the polymer and mucin on mucoadhesion. From the rheological data it can be deduced that the interactions between mucin and JR-30M are mainly based on physical entanglements and less on ionic interactions.

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