Interaction of heparin with defensin, a nonenzymatic cationic protein from neutrophils
Liapina, L.A.; Kondashevskaia, M.V.; Kokriakov, V.N.; Shamova, O.V.
Voprosy Meditsinskoi Khimii 38(1): 39-42
1992
ISSN/ISBN: 0042-8809 PMID: 1441292 Document Number: 398480
Heparin was shown to form complexes with cation non-enzymatic protein defensine from neutrophils. The complex obtained in vitro did not affect the anticoagulation and fibrinolytic properties of blood, whereas defensine decreased the content of heparin, rates of non-enzymatic fibrinolysis and total fibrinolytic activity while heparin stimulated the anticoagulation activity of blood plasma. Interaction of heparin with defensine appears to be involved in protective mechanism responsible for neutralization of both the heparin anticoagulation activity and the defensine properties related to inhibition of nonenzymatic fibrinolysis.