Clinical significance of NADPH-dependent dehydrogenases in lymphocytes from patients with bronchial asthma
Kurtasova, L.M.; Savchenko, A.A.; Puchko, E.A.; Ol'khovskiĭ, I.A.
Klinicheskaia Laboratornaia Diagnostika 8: 3-5
2001
ISSN/ISBN: 0869-2084 PMID: 11582669 Document Number: 539538
The activities of lymphocyte NADP-dependent dehydrogenases were evaluated in 84 children with atopic asthma during relapses and clinical remission. The pattern and severity of changes in the studied enzymes depended on children's age and duration and severity of disease. Changes in the older age group and during relapse were the deepest and most stubborn. During remission the activities of the studied oxidoreductases did not reach the parameters observed in healthy children. Changes in the activities of NADP-dependent dehydrogenases in blood lymphocytes objectively reflect the course of allergic inflammation in patients with atopic asthma and can be clinically used for evaluation of the pathological process at a metabolic level.