Effects of cortisol on calcium contents of lymphocytes in patients with bronchial asthma
Dukhanin, A.S.; Bulaeva, N.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 114(9): 282-284
1992
ISSN/ISBN: 0365-9615 PMID: 1477359 Document Number: 388041
A fluorescent probe was used to study hydrocortisone (10 microM) action on mitogen-stimulated free cytoplasmic calcium level in lymphocytes of patients with bronchial asthma. The patients were divided into two groups according to their sensitivity to glucocorticoid therapy. Hydrocortisone-specific calcium-blocking effect was absent in hormone-resistant patients. Lymphocytes of hormone-sensitive patients responded to hydrocortisone administration by a decline of mitogen-induced calcium level.