Melatonin effects on functional activity of platelets in patients with bronchial asthma
Evsiukova, E.V.
Terapevticheskii Arkhiv 71(12): 35-37
1999
ISSN/ISBN: 0040-3660 PMID: 10647198 Document Number: 507148
To assess effects of epiphysial hormone melatonin in various dose regimens on ADP-induced aggregation of platelets in patients with bronchial asthma (BA). Correlations with urine levels of 6-sulphatoxymelatonin (6-SOMT), basic melatonin metabolite, were made. Melatonin was given to 17 patients with mild or moderate BA and 16 healthy controls. BA patients were found to have disorders in circadian rhythm of urine 6-SOMT excretion, lack of correlation between platelet functional activity and elevated nocturnal excretion of 6-SOMT, in vitro platelet activation in response to low-dose melatonin and absence of this reaction to high-dose melatonin. It is suggested that melatonin may be involved in genesis of bronchoobstructive syndrome in BA.