Effects of angiotensin Ii on proliferation and expression of interleukin-6 of human kidney fibroblasts
Qu, S.; Wang, Z.; Fang, Q.; Chen, G.
Hua Xi Yi Ke da Xue Xue Bao 32(3): 379-381
2001
ISSN/ISBN: 0257-7712 PMID: 12536569 Document Number: 538657
To investigate the effects of Angiotensin(Ang) II on the proliferation and expression of Interleukin (IL)-6 in human kidney fibroblasts(KFB). The human KFB were cultured and identified, the proliferation of KFB was measured by MTT, and the level of IL-6 was measured by radioimmunoassay(RIA). Angiotensin II could stimulate the proliferation of KFB and enhance the expression of IL-6 in protein level on KFB. Angiotensin II can stimulate KFB's proliferation and enhance the expression of IL-6 of KFB. These findings suggest that Ang II might play a part in the mechanisms for modulating tubulointerstitial changes and induceing renal fibrosis.