Expression of bone morphogenetic protein (BMP) -2, 4 in mouse embryonic tooth during the bud stage
Zhang, J.; Tian, W.; Liu, L.; Li, S.; Tang, W.
Hua Xi Kou Qiang Yi Xue Za Zhi 19(6): 392
2001
ISSN/ISBN: 1000-1182 PMID: 12539692 Document Number: 537182
The purpose of this paper was to investigate the distributions of bone morphogenic protein (BMP)-2, 4 in the developing molars of mice during the bud stage and, the functional relationship between BMP-2 and BMP-4. The distribution of BMP-2, 4 were examined in developing mouse molars on the 14th (the 14th embryonic day), using monoclonal antibodies and immunohistochemistry methods. BMP-2, 4 were detected both in the epithelial cells and dental mesenchyme cells. There is a similar distribution pattern between BMP-2 and BMP-4. Therefore, there may be a functional relationship between BMP-2 and BMP-4 during the development of mouse embryonic teeth in the bud stage.