Nebivolol treatment in essential arterial hypertension
Ghiuru, R.; Rezuş, C.; Ambăruş, V.; Ionescu, S.; Cosovanu, A.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 105(4): 756-759
2001
ISSN/ISBN: 0048-7848 PMID: 12092233 Document Number: 534613
Nebivolol is a lipophilic beta 1-blocker. It is devoid of intrinsic sympathomimetic or membrane stabilising activity but appears to have nitric oxide-mediated vasodilatory effects. Nebivolol 5 mg once daily is well tolerated in patients with hypertension. Adverse events are infrequent, transient and mild to moderate. Those reported most often include headache, fatigue, paraesthesias and dizziness. Several studies reported no signs of orthostatic hypotension with Nebivolol.