The levels of interleukin 8 in gingival crevicular fluids of chronic periodontitis
Zou, D.R.; Liu, Y.W.; Chen, Y.; Dai, Q.C.
Shanghai Kou Qiang Yi Xue 10(4): 339-341
2001
ISSN/ISBN: 1006-7248 PMID: 14993968 Document Number: 532096
To study the changes of IL-8 levels in chronic periodontitis progress and correlation with clinical parameters. The concentrations and total amounts of IL-8 cytokine in gingival crevicular fluids by double antibody sandwich ABC ELISA in chronic periodontitis (before and after treatment) and healthy control group were determined. Clinical parameters were measured and analysed. In the chronic periodontitis, IL-8 cytokine was detected,significantly higher than the healthy group. The total amounts of IL-8 and GCF had significant differences between the diseased and healthy groups, as well as between the groups before and after treatment (P<0.01, P<0.05, respectively), but no significant difference was found between these groups in the concentration of IL-8 (P>0.05). There was positive correlation between the total amounts of IL-8 and clinical parameters, between GCF volume and clinical parameters (P<0.01). These data indicated that the total amounts of IL-8 exhibited dynamic changes upon progress of chronic periodontitis. The levels of IL-8 in GCF are valuable in judging the degree of chronic periodontitis and in guiding clinical treatment.