The influences of non-surgical periodontal treatment on gingival crevicular fluid levels of MMP-8 and tissue inhibitor of TIMP-1
Wang, L.-q.; Feng, K.; Sun, L.
Shanghai Kou Qiang Yi Xue 23(2): 229-232
2014
ISSN/ISBN: 1006-7248 PMID: 24935850 Document Number: 678185
To compare the levels of MMP-8 and TIMP-1 in the gingival crevicular fluid (GCF)of chronic periodontitis(CP) patients before and after non-surgical periodontal therapy. Sulcus bleeding index (SBI), plaque index (PLI) and probing depth (PD) were detected before and after therapy. GCF was collected from CP patients before and after therapy. MMP-8 and TIMP-1 were determined by enzyme-linked immunoabsorbent assay. The data was analyzed using paired-sample t test and multi-correlation analysis with SSPS 19.0 software package. The levels of MMP-8 and TIMP-1 decreased after therapy, and there was no significant difference in the MMP-8/TIMP-1 ratio. Correction analysis showed that a significant correction was found between MMP-8 and GCF weight. MMP-8 and TIMP-1 decrease after non-surgical periodontal therapy.