The correlation between interleukin-1 receptor antagonist genotype and coronary heart disease in patients with chronic periodontitis
Chu, M.; Zhong, L.-j.; Li, S.-b.; Yang, K.; Jiang, H.
Shanghai Kou Qiang Yi Xue 18(1): 1-4
2009
ISSN/ISBN: 1006-7248 PMID: 19290417 Document Number: 634266
To investigate the correlation between interleukin-1 receptor antagonist (IL-1ra) genotype and chronic periodontitis in patients with coronary heart disease. Genomic DNA was obtained from buccal swabs in 86 patients with coronary heart disease,of which 45 patients with chronic periodontitis, the other without chronic periodontitis. Genotypes of IL-1RN intron 2 VNTR were analyzed by SSP-PCR method. Then the differences in distribution of each genotype were analyzed with SPSS 13.0 software package. A significant over-representation of IL-1 RN intron 2 VNTR allele 2 was found in patients with coronary heart disease and chronic periodontitis group (chi(2)=4.960,P=0.026). IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of chronic periodontitis in patients with coronary heart disease.