Research on new AMPA antagonists of 2,3-benzodiazepine type
Sólyom, S.
Die Pharmazie 56(Suppl 1): S62-S66
2001
ISSN/ISBN: 0031-7144 PMID: 11686094 Document Number: 532062
In this review on the most interesting studies and discoveries made during our structure-activity relationship investigations with non-competitive AMPA antagonists of 2,3-benzodiazepine type, our chain of ideas is discussed which led to several new types of active non-competitive AMPA antagonists. Some selected compounds (e.g. GYKI-47261) exerting broad spectrum of anticonvulsive and excellent neuroprotective effects are being further investigated.
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