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Opioid benzodiazepine tifluadom and drug-induced hyperactivity in mice: lack of benzodiazepine-like effects

Sansone, M.; Castellano, C.; Pavone, F.; Hano, J.

Polish Journal of Pharmacology and Pharmacy 37(5): 585-590

1985

ISSN/ISBN: 0301-0244
PMID: 2870483
Document Number: 254003
The opioid benzodiazepine, tifluadom, and the benzodiazepine tranquilizer, diazepam, were compared for their influence on morphine and scopolamine-induced locomotor stimulation in mice. Diazepam enhanced drug-induced hyperactivity, while tifluadom had no effect or reduced locomotor activity. The results demonstrate that tifluadom, a benzodiazepine compound possessing opiate-like analgesic properties, is devoid of either benzodiazepine or morphine-like effects in activity tests.

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