Locomotor depression by the opioid benzodiazepine tifluadom in mice
Castellano, C.; Pavone, F.; Sansone, M.
Archives Internationales de Pharmacodynamie et de Therapie 270(2): 318-323
1984
ISSN/ISBN: 0003-9780 PMID: 6091579 Document Number: 234902
Several doses of tifluadom, an opioid benzodiazepine with affinity for opioid kappa receptors, were tested on analgesia and locomotor activity in two strains of mice, the C57BL/6 and the DBA/2. The analgesic properties of the compound were confirmed in both strains by a tail flick test. As concerns locomotor activity both strains, that in previous researches showed opposite responses to opiates, were depressed by tifluadom, suggesting the involvement of kappa receptors in this effect.