Testicular toxicity induced by oral administration of SC-32855, a 1,4-benzodiazepine, in the dog
Means, J.R.; Chengelis, C.P.; Jasty, V.
Research Communications in Chemical Pathology and Pharmacology 37(2): 317-320
1982
ISSN/ISBN: 0034-5164 PMID: 6127762 Document Number: 184745
A 1,4-benzodiazepine, SC-32855, was administered orally once daily at doses of 30, 100, and 300 mg/kg for two weeks to adult Beagle dogs (1/sex/dose). The 300 mg/kg animals were sacrificed in extremis on day three after showing extreme signs of CNS depression. At necropsy, the testes of the 100 mg/kg male weighed considerably less than those of the control. The testicular weights of the 30 and 300 mg/kg animals were comparable to the weight of the control testes. Histopathologic evaluation of the testes of the 100 mg/kg male revealed degenerative and necrotic changes in the seminiferous tubules and cytoplasmic vacuolation in Leydig cells. In the 30 and 300 mg/kg animals, degenerative and necrotic changes were restricted to the seminiferous tubules.