Epidural aspergillosis secondary to lung aspergilloma despite long-term itraconazole treatment
Jeanrot, C.; Guigui, P.; Groussard, O.; Deburge, A.
Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur 87(6): 596-600
2001
ISSN/ISBN: 0035-1040 PMID: 11685151 Document Number: 530684
A 58-year-old man developed spinal cord compression at the T2-T3 level due to an Aspergillus epidural abscess. This presumably immunocompetent patient had been treated for two years by oral itraconazole (200 mg/day) for a lung aspergilloma that occurred seven years after removal of a lung adenocarcinoma. Surgical debridement was performed via a wide posterior approach associated with high-dose amphotericin B. Five months later, the patient's neurological deficit had not improved and the patient died from respiratory failure. Despite a long-term treatment with itraconazole, the infection spread locally from a lung aspergilloma to the epidural space.