Various methods of overcoming secondary resistance to treatment developing in relation to adaptation to psychotropic drugs during long-term treatment (clinico-experimental study)
Avrutskiĭ, G.I.; Allikmets, L.K.; Neduva, A.A.; Zharkovskiĭ, A.M.; Beliakov, A.V.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 84(8): 1213-1220
1984
ISSN/ISBN: 0044-4588 PMID: 6495946 Document Number: 224899
Clinical and experimental studies into the phenomenon of adaptation to neuroleptic agents and into the methods of its overcoming were carried out. An experimental study of the long-term administrations of haloperidol revealed the formation of adaptation to the drug which can be overcome by a zigzag-like sharp elevation of the dosage followed by rapid reduction to the baseline level. The trial of this method under clinical conditions showed that it was expedient to use on a large scale the experimental findings on the specific features of the formation and prevention of the secondary therapeutic resistance.