IGF-1 stimulates mucosal growth in ileal Thiry-Vella fistulas
Hashimoto, N.; Ohyanagi, H.
Hepato-Gastroenterology 48(38): 413-415
2001
ISSN/ISBN: 0172-6390 PMID: 11379320 Document Number: 528368
Background/Aims: We determined whether the trophic effects of IGF-1 (Insulin-like growth factor-1) on the small bowel mucosa are mediated by either nonluminal factors or endogenous luminal secretion. The gut hormone IGF-1 stimulates growth of small bowel mucosa. The mechanism responsible for this trophic effect are not known. Methodology: Rats underwent construction of a Thiry-Vella fistula of ileum. On postoperative day 10, the two groups were subdivided to receive either saline (control) or IGF-1. After 7 days, rats were killed and the Thiry-Vella fistula was removed. The mucosa was scraped and weighed, and protein content and alkaline phosphatase activity was determined. Results: IGF-1 significantly increased mucosal weight and alkaline phosphatase activity and protein content of ileal Thiry-Vella fistula compared with the control rats. Conclusions: IGF-1 mediated stimulation of small bowel mucosal growth is mediated by factors that are independent of luminal contents and pancreaticobiliary secretion. IGF-1 may prove to be an important enterotrophic factor for gut mucosal proliferation.