Anti-Coxsakie B viruses humoral immunity status in patients with pancreatic diseases
Trukhan, D.I.
Voprosy Virusologii 46(2): 33-36
2001
ISSN/ISBN: 0507-4088 PMID: 11392968 Document Number: 526990
Similar titers and incidence of antibodies to group-specific Coxsackie B virus antigen were detected in 137 patients with chronic pancreatitis and 127 patients with insulin-dependent diabetes mellitus (IDDM). Characteristic clinical features of chronic pancreatitis associated with the presence of antibodies to Coxsackie B virus in high titers were detected. HLA Cw2 antigen is significantly more incident in the phenotype of patients with chronic pancreatitis and IDDM and high titers of antibodies to Coxsackie B virus. These data confirm the possible contribution of Coxsackie B virus infection to the development of IDDM and suggest its contribution to development of chronic pancreatitis.