Changes in humoral and cellular immunity in patients operated on due to esophageal cancer
Szczesny, T.; Słotwiński, R.; Szczesny, G.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 18(106): 478-482
2005
ISSN/ISBN: 1426-9686 PMID: 16161939 Document Number: 591547
The aim of this paper was to analyze changes in immune system in patients operated on due to esophageal carcinoma. A special interest was paid to selected parameters of humoral and cellular immunity in peripheral blood as well as local changes in the immune system. A practical aspect of changes in immune system in the diagnosis of postoperative complications was taken into account. Results of the analyzed studies show that in patients with esophageal carcinoma occur significant changes in humoral and cellular immunity which increase the risk of postoperative complications. A high rate of postoperative complications in patients after esophagectomy due to esophageal carcinoma is caused predominantly by preoperative immunocompromised and malnutrition. The extent of operative stress as well as increased activity of immune cells in the early postoperative period, are other factors which increase the risk of severe, especially respiratory complications. It seems that early diagnosis and correction of compromised immunity (for example with nutrition) can significantly improve the results of the treatment.