Gemcitabine in pre-treated advanced renal carcinoma: a feasibility study
Casali, M.; Marcellini, M.; Casali, A.; Giuntini, T.; Galante, E.; Ferrone, C.
Journal of Experimental and Clinical Cancer Research Cr 20(2): 195-198
2001
ISSN/ISBN: 0392-9078 PMID: 11484974 Document Number: 526718
Eigtheen patients affected by metastatic renal cell carcinoma, 16 which were assesable, were treated with 1 g/m2 of Gemcitabine (GCB) on days 1, 8 and 15 of a 28-day treatment cycle up to a maximun of ten cycles. All patients in neoplastic progression were treated with chemo- and immunotherapy (5 FU, IL-2, IFN alpha d 13-cis-retinoic acid.) Out of the 16 assessable patients, 5/16 (31%) showed overall response (ICR, 4 PR), 5 (31%) stable disease (SD) and 6 (38%) progression of disease (PD). Toxicity was limited to WHO grades I only, primarily hematological.
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