Gemcitabine in advanced stage soft tissue sarcoma: a phase Ii study
Amodio, A.; Carpano, S.; Manfredi, C.; Del Monte, G.; Di Lauro, L.; Gionfra, T.; Conti, F.; Paoletti, G.; Lopez, M.
La Clinica Terapeutica 150(1): 17-20
1999
ISSN/ISBN: 0009-9074 PMID: 10367540 Document Number: 511619
To assess the activity and toxicity of gemcitabine in locally advanced or metastatic soft tissue sarcoma patients (pts). Gemcitabine was administered on days 1, 8, 15 every 4 weeks at a dose of 1.000/1.250 mg/m2, respectively, in pretreated or not pretreated pts. Eighteen pts entered this phase II trial; sixteen had been previously treated with anthracyclines and ifosfamide. A partial response was observed in a woman with fibrous malignant istocytoma, whereas in 7 pts the disease remained stable. Median time to progression was 4 months. The treatment was well tolerated. Grade 4 toxicity was not observed. These results do not suggest that gemcitabine, in the dose and schedule used in this trial, may be of value in the treatment of soft tissue sarcomas.