The role of adhesion molecules in atherosclerosis and diabetes mellitus
Gaál, Z.; Ruzicska, E.; Valenta, B.; Somogyi, A.
Orvosi Hetilap 141(46): 2483-2486
2000
ISSN/ISBN: 0030-6002 PMID: 11126680 Document Number: 525688
Adhesion of circulating cells to the vascular endothelium is an early step in the development of atherosclerosis. Diabetic patients have a 2-4 fold increased risk for the development of atherosclerosis. Expression of adhesion molecules is increased in diabetes. These molecules may contribute to accelerated atherosclerosis in diabetes. Three main groups of adhesion molecules have been identified: integrins, selectins and members of the immunoglobulin superfamily. The modulation of expression and activity of adhesion molecules may play an important role in the prevention and treatment of atherosclerosis. This article summarises the characteristics and the role of these molecules in atherosclerosis and diabetes.