The role of adhesion molecules in reperfusion injury
Winn, R.K.; Vedder, N.B.; Mihelcic, D.; Flaherty, L.C.; Langdale, L.; Harlan, J.M.
Agents and Actions. Supplements 41: 113-126
1993
ISSN/ISBN: 0379-0363 PMID: 8317335 Document Number: 405466
Leukocytes can produce vascular injury following ischemia and reperfusion of tissue resulting in thrombosis, edema and necrosis. Leukocyte adhesion to endothelial cells allows formation of a protected microenvironment where inflammatory molecules can exceed anti-inflammatory molecules thus resulting in injury. Blocking adherence with monoclonal antibodies to adherence molecules can prevent reperfusion injury to a variety of organs. In particular, antibodies to CD18 and P-selectin have been shown to be effective in ameliorating injury.